KEGG   REACTION: R04826
Entry
R04826                      Reaction                               
Name
7alpha-hydroxycholest-4-en-3-one,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha-hydroxylating)
Definition
7alpha-Hydroxycholest-4-en-3-one + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 4-Cholesten-7alpha,12alpha-diol-3-one + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C05455 + C03024 + C00007 <=> C17339 + C03161 + C00001
Reaction class
RC01218  C05455_C17339
Enzyme
1.14.14.139
Pathway
rn00120  Primary bile acid biosynthesis
rn01100  Metabolic pathways
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.139
     R04826  7alpha-Hydroxycholest-4-en-3-one + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 4-Cholesten-7alpha,12alpha-diol-3-one + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K07431  sterol 12-alpha-hydroxylase [EC:1.14.14.139]
Other DBs
RHEA: 46755

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (581)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (580)   
All databases (595)   

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